Chicago: Rap star Proof, a founding member of D-12 and close friend of Eminem, was shot dead at a Detroit nightclub on Tuesday.
Proof or DeShaun Holton was killed after a fight broke out at Club CCC on 8 Mile Road, the street memorialised in Eminem's quasi-autobiographical film.
Holton had a small role in the film as a rapper who made Eminem's character choke during an early battle scene.
The character "Future" portrays the influence Proof, who hosted battles at Maurice Malone's Hip Hop Shop, had in helping Eminem rise to fame.
Holton, who was the best man at Eminem's January wedding, recently released a solo album, Searching for Jerry Garcia on his Iron Fist Records label.
In an eerie irony, Holton's character was shot and killed in Eminem's Like Toy Solidiers video which warns against hip-hop wars escalating into violence.
This was the second shooting involving Detroit rap stars in recent months. Obi Trice was shot in the head while driving in Detroit with his girlfriend on New Year's Eve.
The bullet remains lodged in his skull but Trice has recovered and is working on a new album.
Police would not confirm that Holton was the victim, but they said a 32-year-old man was killed after he was shot in the head when a fight broke out about 0400 hrs.
He was carried into a car and but was dead when he arrived at the hospital. A 35-year-old man who was also shot remains in hospital in critical condition, police said.
Police have no suspects in custody and are in the process of investigating a number of leads, Sergeant Omar Feliciano said.
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